Title |
Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains
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Published in |
BMC Genomics, July 2013
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DOI | 10.1186/1471-2164-14-467 |
Pubmed ID | |
Authors |
Ninghan Yang, Andrew Farrell, Wendy Niedelman, Mariane Melo, Diana Lu, Lindsay Julien, Gabor T Marth, Marc-Jan Gubbels, Jeroen PJ Saeij |
Abstract |
Toxoplasma gondii has a largely clonal population in North America and Europe, with types I, II and III clonal lineages accounting for the majority of strains isolated from patients. RH, a particular type I strain, is most frequently used to characterize Toxoplasma biology. However, compared to other type I strains, RH has unique characteristics such as faster growth, increased extracellular survival rate and inability to form orally infectious cysts. Thus, to identify candidate genes that could account for these parasite phenotypic differences, we determined genetic differences and differential parasite gene expression between RH and another type I strain, GT1. Moreover, as differences in host cell modulation could affect Toxoplasma replication in the host, we determined differentially modulated host processes among the type I strains through host transcriptional profiling. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 20% |
Germany | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 1% |
Unknown | 83 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 27 | 32% |
Researcher | 14 | 17% |
Student > Doctoral Student | 8 | 10% |
Student > Master | 6 | 7% |
Student > Bachelor | 5 | 6% |
Other | 9 | 11% |
Unknown | 15 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 31 | 37% |
Biochemistry, Genetics and Molecular Biology | 19 | 23% |
Immunology and Microbiology | 11 | 13% |
Medicine and Dentistry | 2 | 2% |
Unspecified | 1 | 1% |
Other | 2 | 2% |
Unknown | 18 | 21% |