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Immunoglobulins in COVID-19 pneumonia: from the acute phase to the recovery phase

Overview of attention for article published in European Journal of Medical Research, April 2024
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Title
Immunoglobulins in COVID-19 pneumonia: from the acute phase to the recovery phase
Published in
European Journal of Medical Research, April 2024
DOI 10.1186/s40001-024-01824-5
Pubmed ID
Authors

Joaquim Peraire, Graciano García-Pardo, Silvia Chafino, Alba Sánchez, Maryluz Botero-Gallego, Montserrat Olona, Sonia Espineira, Laia Reverté, Vasso Skouridou, Óscar M. Peiró, Fréderic Gómez-Bertomeu, Francesc Vidal, Ciara K. O’ Sullivan, Anna Rull

Abstract

COVID-19 pneumonia causes hyperinflammatory response that culminates in acute respiratory syndrome (ARDS) related to increased multiorgan dysfunction and mortality risk. Antiviral-neutralizing immunoglobulins production reflect the host humoral status and illness severity, and thus, immunoglobulin (Ig) circulating levels could be evidence of COVID-19 prognosis. The relationship among circulating immunoglobulins (IgA, IgG, IgM) and COVID-19 pneumonia was evaluated using clinical information and blood samples in a COVID-19 cohort composed by 320 individuals recruited during the acute phase and followed up to 4 to 8 weeks (n = 252) from the Spanish first to fourth waves. COVID-19 pneumonia development depended on baseline Ig concentrations. Circulating IgA levels together with clinical features at acute phase was highly associated with COVID-19 pneumonia development. IgM was positively correlated with obesity (ρb = 0.156, P = 0.020), dyslipemia (ρb = 0.140, P = 0.029), COPD (ρb = 0.133, P = 0.037), cancer (ρb = 0.173, P = 0.007) and hypertension (ρb = 0.148, P = 0.020). Ig concentrations at recovery phase were related to COVID-19 treatments. Our results provide valuable information on the dynamics of immunoglobulins upon SARS-CoV-2 infection or other similar viruses.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 1 33%
Unspecified 1 33%
Librarian 1 33%
Readers by discipline Count As %
Unspecified 1 33%
Biochemistry, Genetics and Molecular Biology 1 33%
Medicine and Dentistry 1 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2024.
All research outputs
#17,684,441
of 25,809,966 outputs
Outputs from European Journal of Medical Research
#456
of 947 outputs
Outputs of similar age
#85,804
of 169,721 outputs
Outputs of similar age from European Journal of Medical Research
#9
of 19 outputs
Altmetric has tracked 25,809,966 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 947 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,721 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.