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Mendeley readers
| Title |
Plasmodium falciparumencodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy
|
|---|---|
| Published in |
BMC Biology, July 2013
|
| DOI | 10.1186/1741-7007-11-80 |
| Pubmed ID | |
| Authors |
Aline Fréville, Katia Cailliau-Maggio, Christine Pierrot, Géraldine Tellier, Hadidjatou Kalamou, Sophia Lafitte, Alain Martoriati, Raymond J Pierce, Jean-François Bodart, Jamal Khalife |
| Abstract |
It is clear that the coordinated and reciprocal actions of kinases and phosphatases are fundamental in the regulation of development and growth of the malaria parasite. Protein Phosphatase type 1 is a key enzyme playing diverse and essential roles in cell survival. Its dephosphorylation activity/specificity is governed by the interaction of its catalytic subunit (PP1c) with regulatory proteins. Among these, inhibitor-2 (I2) is one of the most evolutionarily ancient PP1 regulators. In vivo studies in various organisms revealed a defect in chromosome segregation and cell cycle progression when the function of I2 is blocked. |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| South Africa | 1 | 3% |
| Unknown | 37 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 26% |
| Researcher | 7 | 18% |
| Student > Bachelor | 3 | 8% |
| Professor | 2 | 5% |
| Student > Doctoral Student | 2 | 5% |
| Other | 10 | 26% |
| Unknown | 5 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 33% |
| Biochemistry, Genetics and Molecular Biology | 10 | 26% |
| Medicine and Dentistry | 3 | 8% |
| Computer Science | 2 | 5% |
| Chemistry | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 7 | 18% |