Title |
Estimating parameters for generalized mass action models with connectivity information
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Published in |
BMC Bioinformatics, May 2009
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DOI | 10.1186/1471-2105-10-140 |
Pubmed ID | |
Authors |
Chih-Lung Ko, Eberhard O Voit, Feng-Sheng Wang |
Abstract |
Determining the parameters of a mathematical model from quantitative measurements is the main bottleneck of modelling biological systems. Parameter values can be estimated from steady-state data or from dynamic data. The nature of suitable data for these two types of estimation is rather different. For instance, estimations of parameter values in pathway models, such as kinetic orders, rate constants, flux control coefficients or elasticities, from steady-state data are generally based on experiments that measure how a biochemical system responds to small perturbations around the steady state. In contrast, parameter estimation from dynamic data requires time series measurements for all dependent variables. Almost no literature has so far discussed the combined use of both steady-state and transient data for estimating parameter values of biochemical systems. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 10% |
New Zealand | 1 | 2% |
Germany | 1 | 2% |
Vietnam | 1 | 2% |
Unknown | 41 | 84% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 35% |
Researcher | 11 | 22% |
Professor > Associate Professor | 5 | 10% |
Student > Bachelor | 4 | 8% |
Student > Postgraduate | 3 | 6% |
Other | 5 | 10% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 29% |
Engineering | 11 | 22% |
Biochemistry, Genetics and Molecular Biology | 10 | 20% |
Computer Science | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 5 | 10% |
Unknown | 6 | 12% |