Title |
Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses
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Published in |
Respiratory Research, October 2007
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DOI | 10.1186/1465-9921-8-73 |
Pubmed ID | |
Authors |
John M Nicholls, Anthony J Bourne, Honglin Chen, Yi Guan, JS Malik Peiris |
Abstract |
Influenza virus binds to cell receptors via sialic acid (SA) linked glycoproteins. They recognize SA on host cells through their haemagglutinins (H). The distribution of SA on cell surfaces is one determinant of host tropism and understanding its expression on human cells and tissues is important for understanding influenza pathogenesis. The objective of this study therefore was to optimize the detection of alpha2,3-linked and alpha2,6-linked SA by lectin histochemistry by investigating the binding of Sambucus nigra agglutinin (SNA) for SAalpha2,6Gal and Maackia amurensis agglutinin (MAA) for SAalpha2,3Gal in the respiratory tract of normal adults and children. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 1% |
United States | 2 | <1% |
Vietnam | 1 | <1% |
Netherlands | 1 | <1% |
Singapore | 1 | <1% |
Canada | 1 | <1% |
China | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 192 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 56 | 28% |
Researcher | 43 | 21% |
Student > Master | 25 | 12% |
Student > Bachelor | 21 | 10% |
Student > Doctoral Student | 9 | 4% |
Other | 23 | 11% |
Unknown | 26 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 74 | 36% |
Biochemistry, Genetics and Molecular Biology | 22 | 11% |
Medicine and Dentistry | 20 | 10% |
Immunology and Microbiology | 16 | 8% |
Veterinary Science and Veterinary Medicine | 16 | 8% |
Other | 23 | 11% |
Unknown | 32 | 16% |