Vanessa Nieratschker, Anil Batra, Andreas J Fallgatter
Abstract
Alcohol dependence is a severe and common disorder associated with high morbidity and mortality rates. Genetic as well as environmental factors are known to modulate susceptibility to alcohol dependence. There is a growing body of evidence suggesting that this interaction between the genome and the environment is mediated by epigenetic mechanisms, e.g. DNA methylation at CpG sites. Following an introduction of epigenetic regulation of gene transcription, this review will provide an overview over recent genetic and epigenetic findings in the context of alcohol dependence focusing on human studies. Finally, we will discuss the current limitations of epigenetic studies as well as the implications of genetic and epigenetic findings for the development of better treatment and prevention strategies.
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2017.
All research outputs
#1,157,563
of 26,406,115 outputs
Outputs from Journal of Molecular Psychiatry
#4
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Outputs of similar age
#9,129
of 208,167 outputs
Outputs of similar age from Journal of Molecular Psychiatry
#1
of 7 outputs
Altmetric has tracked 26,406,115 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 30 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one scored the same or higher as 26 of them.
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We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them
