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Mendeley readers
Attention Score in Context
| Title |
Placental DNA hypomethylation in association with particulate air pollution in early life
|
|---|---|
| Published in |
Particle and Fibre Toxicology, June 2013
|
| DOI | 10.1186/1743-8977-10-22 |
| Pubmed ID | |
| Authors |
Bram G Janssen, Lode Godderis, Nicky Pieters, Katrien Poels, Michał Kiciński, Ann Cuypers, Frans Fierens, Joris Penders, Michelle Plusquin, Wilfried Gyselaers, Tim S Nawrot |
| Abstract |
BACKGROUND: There is evidence that altered DNA methylation is an important epigenetic mechanism in prenatal programming and that developmental periods are sensitive to environmental stressors. We hypothesized that exposure to fine particles (PM2.5) during pregnancy could influence DNA methylation patterns of the placenta. METHODS: In the ENVIRONAGE birth cohort, levels of 5'-methyl-deoxycytidine (5-mdC) and deoxycytidine (dC) were quantified in placental DNA from 240 newborns. Multiple regression models were used to study placental global DNA methylation and in utero exposure to PM2.5 over various time windows during pregnancy. RESULTS: PM2.5 exposure during pregnancy averaged (25th-75th percentile) 17.4 (15.4-19.3) mug/m3. Placental global DNA methylation was inversely associated with PM2.5 exposures during whole pregnancy and relatively decreased by 2.19% (95% confidence interval (CI): -3.65, -0.73%, p = 0.004) for each 5 mug/m3 increase in exposure to PM2.5. In a multi-lag model in which all three trimester exposures were fitted as independent variables in the same regression model, only exposure to PM2.5 during trimester 1 was significantly associated with lower global DNA methylation (-2.13% per 5 mug/m3 increase, 95% CI: -3.71, -0.54%, p = 0.009). When we analyzed shorter time windows of exposure within trimester 1, we observed a lower placental DNA methylation at birth during all implantation stages but exposure during the implantation range (6-21d) was strongest associated (-1.08% per 5 mug/m3 increase, 95% CI: -1.80, -0.36%, p = 0.004). CONCLUSIONS: We observed a lower degree of placental global DNA methylation in association with exposure to particulate air pollution in early pregnancy, including the critical stages of implantation. Future studies should elucidate genome-wide and gene-specific methylation patterns in placental tissue that could link particulate exposure during in utero life and early epigenetic modulations. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Unknown | 156 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 17% |
| Researcher | 21 | 13% |
| Student > Bachelor | 16 | 10% |
| Student > Master | 14 | 9% |
| Student > Doctoral Student | 12 | 8% |
| Other | 26 | 17% |
| Unknown | 41 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 19% |
| Biochemistry, Genetics and Molecular Biology | 17 | 11% |
| Agricultural and Biological Sciences | 13 | 8% |
| Environmental Science | 13 | 8% |
| Nursing and Health Professions | 7 | 4% |
| Other | 21 | 13% |
| Unknown | 56 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2015.
All research outputs
#14,822,418
of 23,709,010 outputs
Outputs from Particle and Fibre Toxicology
#353
of 584 outputs
Outputs of similar age
#113,514
of 199,119 outputs
Outputs of similar age from Particle and Fibre Toxicology
#7
of 7 outputs
Altmetric has tracked 23,709,010 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 584 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.0. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,119 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.