Title |
Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment
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Published in |
BMC Genomics, July 2013
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DOI | 10.1186/1471-2164-14-469 |
Pubmed ID | |
Authors |
Tamasin N Doig, David A Hume, Thanasis Theocharidis, John R Goodlad, Christopher D Gregory, Tom C Freeman |
Abstract |
Biopsies taken from individual tumours exhibit extensive differences in their cellular composition due to the inherent heterogeneity of cancers and vagaries of sample collection. As a result genes expressed in specific cell types, or associated with certain biological processes are detected at widely variable levels across samples in transcriptomic analyses. This heterogeneity also means that the level of expression of genes expressed specifically in a given cell type or process, will vary in line with the number of those cells within samples or activity of the pathway, and will therefore be correlated in their expression. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 5% |
United Kingdom | 2 | 3% |
Spain | 1 | 2% |
Norway | 1 | 2% |
Unknown | 52 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 19% |
Researcher | 11 | 19% |
Student > Doctoral Student | 4 | 7% |
Professor > Associate Professor | 4 | 7% |
Student > Master | 4 | 7% |
Other | 10 | 17% |
Unknown | 15 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 27% |
Biochemistry, Genetics and Molecular Biology | 13 | 22% |
Computer Science | 4 | 7% |
Immunology and Microbiology | 3 | 5% |
Medicine and Dentistry | 3 | 5% |
Other | 5 | 8% |
Unknown | 15 | 25% |