Daniel Habermehl, Klaus K Herfarth, Justo Lorenzo Bermejo, Holger Hof, Stefan Rieken, Sabine Kuhn, Thomas Welzel, Jürgen Debus, Stephanie E Combs
Abstract
Local ablative therapies such as stereotactically guided single-dose radiotherapy or helical intensity-modulated radiotherapy (tomotherapy) with high single-doses are successfully applied in many centers in patients with liver metastasis not suitable for surgical resection. This study presents results from more than 10 years of clinical experience and evaluates long-term outcome and efficacy of this therapeutic approach.Patients and methodsFrom 1997 to 2009 a total of 138 intrahepatic tumors of 90 patients were irradiated with single doses of 17 to 30 Gy (median dose 24 Gy). Median age of the patients was 64 years (range 31--89 years). Most frequent underlying tumor histologies were colorectal adenocarcinoma (70 lesions) and breast cancer (27 lesions). In 35 treatment sessions multiple targets up to four lesions at once were irradiated simultaneously. Local progression-free (PFS) and overall survival (OS) from treatment day on were investigated using uni- and multivariable survival regression models.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2015.
All research outputs
#13,154,684
of 22,714,025 outputs
Outputs from Radiation Oncology
#598
of 2,046 outputs
Outputs of similar age
#100,448
of 194,246 outputs
Outputs of similar age from Radiation Oncology
#9
of 38 outputs
Altmetric has tracked 22,714,025 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,046 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
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We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.
