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Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma

Overview of attention for article published in Allergy, Asthma & Clinical Immunology, February 2017
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Title
Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma
Published in
Allergy, Asthma & Clinical Immunology, February 2017
DOI 10.1186/s13223-017-0182-0
Pubmed ID
Authors

Rachel Caswell-Smith, Terrianne Cripps, Thom Charles, Alexander Hosking, Meghana Handigol, Cecile Holweg, John Matthews, Mark Holliday, Corentin Maillot, James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, On behalf of the Periostin Study Team

Abstract

We aimed to determine the effect of sampling time during the day on serum periostin levels in adult participants with and without asthma. Serum periostin was measured at 2-h intervals from 0800 to 1800 h in 16 adult participants with stable asthma prescribed inhaled corticosteroid and long-acting beta-agonist therapy, and in 16 otherwise healthy participants without asthma. Mixed linear models were used to compare time zero (08:00 h) with subsequent measurement time for serum periostin for both groups. In both asthma and non-asthma, the mean (SD) serum periostin levels continuously reduced during the day from 53.5 (13.6) ng/mL at 0800 h to 50.9 (13.4) ng/mL at 1800 h (difference log periostin -0.05, P ≤ 0.001) and 50.5 (13.0) ng/mL at 0800 h to 46.2 (11.5) ng/mL at 1800 h (difference log periostin -0.08, P ≤ 0.001) respectively. Periostin values are higher in the morning compared with the afternoon in asthmatic and non-asthmatic adults. The small magnitude of the variation in serum periostin levels suggests that the time of day in which the serum periostin measurements are made is unlikely to influence treatment decisions if a specific serum periostin level is used to predict treatment responsiveness. Trial registration Australia New Zealand Trials Registry (ACTRN12614000072617).

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 32%
Researcher 4 21%
Student > Doctoral Student 2 11%
Other 1 5%
Student > Bachelor 1 5%
Other 3 16%
Unknown 2 11%
Readers by discipline Count As %
Medicine and Dentistry 13 68%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Social Sciences 1 5%
Agricultural and Biological Sciences 1 5%
Unknown 3 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2017.
All research outputs
#20,660,571
of 25,382,440 outputs
Outputs from Allergy, Asthma & Clinical Immunology
#784
of 924 outputs
Outputs of similar age
#321,956
of 424,548 outputs
Outputs of similar age from Allergy, Asthma & Clinical Immunology
#12
of 15 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.