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The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?

Overview of attention for article published in BMC Biology, July 2013
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Title
The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
Published in
BMC Biology, July 2013
DOI 10.1186/1741-7007-11-79
Pubmed ID
Authors

Matthew D Hall, Dieter Ebert

Abstract

Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial. Here, we focus on the debate surrounding the evolutionary importance of interactions between resistance loci and argue that its role in explaining overall variance in disease outcomes may have been overestimated.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 2 2%
United States 2 2%
Portugal 1 <1%
United Kingdom 1 <1%
India 1 <1%
Russia 1 <1%
Poland 1 <1%
Unknown 94 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 26%
Researcher 22 21%
Student > Master 14 14%
Professor 8 8%
Professor > Associate Professor 6 6%
Other 14 14%
Unknown 12 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 65 63%
Biochemistry, Genetics and Molecular Biology 9 9%
Computer Science 4 4%
Medicine and Dentistry 3 3%
Immunology and Microbiology 2 2%
Other 7 7%
Unknown 13 13%