Title |
Rationale and design of the Sodium Lowering In Dialysate (SoLID) trial: a randomised controlled trial of low versus standard dialysate sodium concentration during hemodialysis for regression of left ventricular mass
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Published in |
BMC Nephrology, July 2013
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DOI | 10.1186/1471-2369-14-149 |
Pubmed ID | |
Authors |
Joanna Leigh Dunlop, Alain Charles Vandal, Janak Rashme de Zoysa, Ruvin Sampath Gabriel, Imad Adbi Haloob, Christopher John Hood, Philip James Matheson, David Owen Ross McGregor, Kannaiyan Samuel Rabindranath, David John Semple, Mark Roger Marshall |
Abstract |
The current literature recognises that left ventricular hypertrophy makes a key contribution to the high rate of premature cardiovascular mortality in dialysis patients. Determining how we might intervene to ameliorate left ventricular hypertrophy in dialysis populations has become a research priority. Reducing sodium exposure through lower dialysate sodium may be a promising intervention in this regard. However there is clinical equipoise around this intervention because the benefit has not yet been demonstrated in a robust prospective clinical trial, and several observational studies have suggested sodium lowering interventions may be deleterious in some dialysis patients. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 14% |
Researcher | 6 | 12% |
Student > Postgraduate | 5 | 10% |
Student > Ph. D. Student | 5 | 10% |
Student > Bachelor | 4 | 8% |
Other | 6 | 12% |
Unknown | 16 | 33% |
Readers by discipline | Count | As % |
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Nursing and Health Professions | 3 | 6% |
Psychology | 3 | 6% |
Economics, Econometrics and Finance | 2 | 4% |
Immunology and Microbiology | 1 | 2% |
Other | 8 | 16% |
Unknown | 17 | 35% |