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Attention Score in Context
| Title |
Study of phytochemical, anti-microbial, anti-oxidant, and anti-cancer properties of Allium wallichii
|
|---|---|
| Published in |
BMC Complementary Medicine and Therapies, February 2017
|
| DOI | 10.1186/s12906-017-1622-6 |
| Pubmed ID | |
| Authors |
Jaya Bhandari, BushraTaj Muhammad, Pratiksha Thapa, Bhupal Govinda Shrestha |
| Abstract |
There is growing interest in the use of plants for the treatment and prevention of cancer. Medicinal plants are currently being evaluated as source of promising anticancer agents. In this paper, we have investigated the anticancer potential of plant Allium wallichii, a plant native to Nepal and growing at elevations of 2300-4800 m. This is the first study of its kind for the plant mentioned. The dried plant was extracted in aqueous ethanol. Phytochemical screening, anti-microbial assay, anti-oxidant assay, cytotoxicity assay and the flow-cytometric analysis were done for analyzing different phytochemicals present, anti-microbial activity, anti-oxidant activity and anti-cancer properties of Allium wallichii. We observed the presence of steroids, terpenoids, flavonoids, reducing sugars and glycosides in the plant extract and the plant showed moderate anti-microbial and anti-oxidant activity. The IC50 values of Allium wallichii in different cancer cell lines are 69.69 μg/ml for Prostate cancer (PC3) cell line, 55.29 μg/ml for Breast Cancer (MCF-7) cell line and 46.51 μg/ml for cervical cancer (HeLa) cell line as compared to Doxorubicin (0.85 μg/ml). The cell viability assay using FACS showed that the IC50value of Allium wallichii for Burkitt's lymphoma (B-Lymphoma) cell line was 3.817 ± 1.99 mg/ml. Allium wallichii can be an important candidate to be used as an anticancer agent. Separation of pure compounds with bioassay guided extraction, spectrometric analysis and subsequent cytotoxicity assay of the pure bioactive compounds from Allium wallichii is highly recommended as the crude extract itself showed promising cytotoxicity. |
Mendeley readers
The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 135 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 13% |
| Student > Master | 14 | 10% |
| Researcher | 11 | 8% |
| Student > Bachelor | 11 | 8% |
| Student > Postgraduate | 7 | 5% |
| Other | 17 | 13% |
| Unknown | 57 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 21 | 16% |
| Agricultural and Biological Sciences | 12 | 9% |
| Medicine and Dentistry | 10 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 7% |
| Nursing and Health Professions | 6 | 4% |
| Other | 17 | 13% |
| Unknown | 60 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2017.
All research outputs
#20,403,545
of 22,953,506 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,985
of 3,639 outputs
Outputs of similar age
#355,960
of 420,410 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#75
of 91 outputs
Altmetric has tracked 22,953,506 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,639 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,410 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.