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Characterization and complete genome of the virulent Myoviridae phage JD007 active against a variety of Staphylococcus aureus isolates from different hospitals in Shanghai, China

Overview of attention for article published in Virology Journal, February 2017
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

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Title
Characterization and complete genome of the virulent Myoviridae phage JD007 active against a variety of Staphylococcus aureus isolates from different hospitals in Shanghai, China
Published in
Virology Journal, February 2017
DOI 10.1186/s12985-017-0701-0
Pubmed ID
Authors

Zelin Cui, Tingting Feng, Feifei Gu, Qingtian Li, Ke Dong, Yan Zhang, Yongzhang Zhu, Lizhong Han, Jinhong Qin, Xiaokui Guo

Abstract

The implementation of phage therapy is re-emerging with the increase in widespread antibiotic-resistant bacteria. Staphylococcus phage JD007 was characterized and its complete genome sequence analysed. Staphylococcus phage JD007 was classified as belonging to the Myoviridae family based on its morphology, as observed by transmission electron microscopy. Its lytic activity was stable between pH 5-11 and below 42 °C; moreover, an absorbance curve showed that nearly 90% of the viral particles had adsorbed to its host after a 20 min co-incubation. The complete genome size is 141,836 bp, making JD007 one of the largest Staphylococcus phages of Myoviridae. No identifiable resistance or virulence genes were found in the JD007 genome. JD007 was able to lyse 95% of S. aureus isolates, including the prevalent ST239-MRSA and ST59-MRSA strains isolated from different hospitals in Shanghai, China, and inhibition assays showed that JD007 could inhibit S. aureus growth at a multiplicity of infection of 0.1. The results suggested that Staphylococcus phage JD007 can potentially be used in phage therapy or for the detection of S. aureus.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 19%
Student > Bachelor 10 15%
Student > Ph. D. Student 9 13%
Researcher 4 6%
Other 3 4%
Other 5 7%
Unknown 24 35%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 18%
Medicine and Dentistry 10 15%
Immunology and Microbiology 7 10%
Agricultural and Biological Sciences 6 9%
Chemical Engineering 1 1%
Other 3 4%
Unknown 29 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2017.
All research outputs
#12,963,412
of 22,953,506 outputs
Outputs from Virology Journal
#1,204
of 3,056 outputs
Outputs of similar age
#197,976
of 420,410 outputs
Outputs of similar age from Virology Journal
#22
of 63 outputs
Altmetric has tracked 22,953,506 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,056 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,410 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.