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Risk factors for excessively prolonged meropenem use in the intensive care setting: a case-control study

Overview of attention for article published in BMC Infectious Diseases, February 2017
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  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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5 tweeters

Citations

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3 Dimensions

Readers on

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46 Mendeley
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Title
Risk factors for excessively prolonged meropenem use in the intensive care setting: a case-control study
Published in
BMC Infectious Diseases, February 2017
DOI 10.1186/s12879-017-2229-8
Pubmed ID
Authors

Juri Katchanov, Benno Kreuels, Florian P. Maurer, Kai Wöstmann, Johannes Jochum, Christina König, Kariem Seoudy, Holger Rohde, Ansgar W. Lohse, Dominic Wichmann, Michael Baehr, Camilla Rothe, Stefan Kluge

Abstract

Inappropriate use of broad-spectrum antimicrobials affects adversely both the individual patient and the general public. The aim of the study was to identify patients at risk for excessively prolonged carbapenem treatment in the ICU as a target for antimicrobial stewardship interventions. Case-control study in a network of 11 ICUs of a university hospital. Patients with uninterrupted meropenem therapy (MT) > 4 weeks were compared to controls. Controls were defined as patients who stayed on the ICU > 4 weeks and received meropenem for ≤ 2 weeks. Associations between case-control status and potential risk factors were determined in a multivariate logistic regression model. Between 1(st) of January 2013 and 31(st) of December 2015, we identified 36 patients with uninterrupted MT > 4 weeks. Patients with prolonged MT were more likely to be surgical patients (72.2% of cases vs. 31.5% of controls; p ≤ 0.001) with peritonitis being the most common infection (n = 16, 44.4%). In the multivariate logistic regression model colonization with multidrug-resistant (MDR) Gram-negative bacteria (OR 7.52; 95% CI 1.88-30.14, p = 0.004) and the type of infection (peritonitis vs. pneumonia: OR 16.96, 95% CI 2.95-97.49) were associated with prolonged MT. Surgical patients with peritonitis and patients with known colonization with MDR Gram-negative bacteria are at risk for excessively prolonged carbapenem therapy and represent an important target population for antimicrobial stewardship interventions.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 20%
Student > Bachelor 5 11%
Student > Postgraduate 4 9%
Other 3 7%
Lecturer 3 7%
Other 11 24%
Unknown 11 24%
Readers by discipline Count As %
Medicine and Dentistry 17 37%
Agricultural and Biological Sciences 4 9%
Biochemistry, Genetics and Molecular Biology 3 7%
Nursing and Health Professions 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 3 7%
Unknown 14 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2017.
All research outputs
#3,800,026
of 9,128,382 outputs
Outputs from BMC Infectious Diseases
#1,331
of 4,013 outputs
Outputs of similar age
#121,559
of 313,746 outputs
Outputs of similar age from BMC Infectious Diseases
#70
of 134 outputs
Altmetric has tracked 9,128,382 research outputs across all sources so far. This one has received more attention than most of these and is in the 57th percentile.
So far Altmetric has tracked 4,013 research outputs from this source. They receive a mean Attention Score of 4.1. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,746 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 134 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.