Title |
Identification of a neuronal transcription factor network involved in medulloblastoma development
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Published in |
Acta Neuropathologica Communications, July 2013
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DOI | 10.1186/2051-5960-1-35 |
Pubmed ID | |
Authors |
Maria Łastowska, Hani Al-Afghani, Haya H Al-Balool, Harsh Sheth, Emma Mercer, Jonathan M Coxhead, Chris PF Redfern, Heiko Peters, Alastair D Burt, Mauro Santibanez-Koref, Chris M Bacon, Louis Chesler, Alistair G Rust, David J Adams, Daniel Williamson, Steven C Clifford, Michael S Jackson |
Abstract |
Medulloblastomas, the most frequent malignant brain tumours affecting children, comprise at least 4 distinct clinicogenetic subgroups. Aberrant sonic hedgehog (SHH) signalling is observed in approximately 25% of tumours and defines one subgroup. Although alterations in SHH pathway genes (e.g. PTCH1, SUFU) are observed in many of these tumours, high throughput genomic analyses have identified few other recurring mutations. Here, we have mutagenised the Ptch+/- murine tumour model using the Sleeping Beauty transposon system to identify additional genes and pathways involved in SHH subgroup medulloblastoma development. |
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United Kingdom | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Canada | 2 | 3% |
Unknown | 72 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 15% |
Student > Bachelor | 9 | 12% |
Student > Master | 7 | 9% |
Professor | 4 | 5% |
Other | 10 | 14% |
Unknown | 13 | 18% |
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Computer Science | 2 | 3% |
Other | 2 | 3% |
Unknown | 20 | 27% |