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Expression of human Piwi-likegenes is associated with prognosis for soft tissue sarcoma patients

Overview of attention for article published in BMC Cancer, June 2012
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

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19 Dimensions

Readers on

mendeley
23 Mendeley
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Title
Expression of human Piwi-likegenes is associated with prognosis for soft tissue sarcoma patients
Published in
BMC Cancer, June 2012
DOI 10.1186/1471-2407-12-272
Pubmed ID
Authors

Thomas Greither, Franziska Koser, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Steffen Göbel, Hans-Jürgen Holzhausen, Sven Wach, Peter Würl, Helge Taubert

Abstract

Argonaute genes are essential for RNA interference, stem cell maintenance and differentiation. The Piwi-like genes, a subclass of the Argonaute genes, are expressed mainly in the germline. These genes may be re-expressed in tumors, and expression of the Piwi-like genes is associated with prognosis in several types of tumors. We measured the expression of Piwi-like mRNAs (Piwi-like 2-4) in 125 soft tissue sarcoma (STS) samples by qPCRs. Statistical tests were applied to study the correlation of expression levels with tumor-specific survival for STS patients. In multivariate Cox's regression analyses, we showed that low Piwi-like 2 and Piwi-like 4 mRNA expression were significantly associated with a worse prognosis (RR = 1.87; p = 0.032 and RR = 1.82; p = 0.039). Low expression of both genes was associated with a 2.58-fold increased risk of tumor-related death (p = 0.01). Piwi-like 4 and combined Piwi-like 2 and 4 mRNA levels correlated significantly with prognosis (RR = 3.53; p = 0.002 and RR = 5.23; p = 0.004) only for female but not for male patients. However, combined low Piwi-like 2 and 3 transcript levels were associated with worse survival (RR = 5.90; p = 0.02) for male patients. In this study, we identified a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients. Furthermore, a connection between sex and the impact of Piwi-like mRNA expressions on STS patients' prognosis was shown for the first time.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 22%
Researcher 5 22%
Student > Bachelor 3 13%
Professor 2 9%
Student > Ph. D. Student 2 9%
Other 3 13%
Unknown 3 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 30%
Agricultural and Biological Sciences 6 26%
Medicine and Dentistry 4 17%
Philosophy 1 4%
Unknown 5 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2017.
All research outputs
#2,396,450
of 9,048,564 outputs
Outputs from BMC Cancer
#679
of 3,723 outputs
Outputs of similar age
#108,180
of 313,287 outputs
Outputs of similar age from BMC Cancer
#32
of 83 outputs
Altmetric has tracked 9,048,564 research outputs across all sources so far. This one has received more attention than most of these and is in the 59th percentile.
So far Altmetric has tracked 3,723 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,287 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.