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The association between vancomycin trough concentrations and acute kidney injury in the neonatal intensive care unit

Overview of attention for article published in BMC Pediatrics, February 2017
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Title
The association between vancomycin trough concentrations and acute kidney injury in the neonatal intensive care unit
Published in
BMC Pediatrics, February 2017
DOI 10.1186/s12887-017-0777-0
Pubmed ID
Authors

Vidit Bhargava, Michael Malloy, Rafael Fonseca

Abstract

Vancomycin has recently gained popularity as an empiric therapy for late onset sepsis in the NICU. Changes in resistance patterns in common organisms has resulted in targeting higher trough concentrations of vancomycin. Consequently, an increase in vancomycin associated nephrotoxicity has been speculated. The objective of this study is to compare the incidence of acute kidney injury (AKI) in neonates with serum vancomycin trough concentrations less than 10 mg/L, 10-15 mg/L, or greater than 15 mg/L. A retrospective chart review of patients in the neonatal intensive care unit (NICU) was conducted to determine the incidence of AKI in neonates receiving vancomycin. The overall incidence of AKI was 2.7%. Comparison of the incidence of AKI in the three groups using Mantel-Haenszel Chi-Square test showed a statistically significant association between increasing vancomycin trough concentration and incidence of AKI. There is a low incidence of AKI in neonates receiving vancomycin. However, there is a positive correlation between increasing vancomycin trough concentrations and an increasing serum creatinine.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 15%
Student > Bachelor 9 15%
Other 7 12%
Student > Master 5 8%
Student > Doctoral Student 4 7%
Other 12 20%
Unknown 14 23%
Readers by discipline Count As %
Medicine and Dentistry 21 35%
Pharmacology, Toxicology and Pharmaceutical Science 8 13%
Biochemistry, Genetics and Molecular Biology 3 5%
Agricultural and Biological Sciences 2 3%
Psychology 2 3%
Other 7 12%
Unknown 17 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2017.
All research outputs
#18,616,159
of 23,881,329 outputs
Outputs from BMC Pediatrics
#2,364
of 3,143 outputs
Outputs of similar age
#302,484
of 428,389 outputs
Outputs of similar age from BMC Pediatrics
#44
of 56 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,143 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 428,389 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.