Title |
Sp1- and Krüppel-like transcription factors
|
---|---|
Published in |
Genome Biology, February 2003
|
DOI | 10.1186/gb-2003-4-2-206 |
Pubmed ID | |
Authors |
Joanna Kaczynski, Tiffany Cook, Raul Urrutia |
Abstract |
Sp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that are important components of the eukaryotic cellular transcriptional machinery. By regulating the expression of a large number of genes that have GC-rich promoters, Sp1-like/KLF transcription regulators may take part in virtually all facets of cellular function, including cell proliferation, apoptosis, differentiation, and neoplastic transformation. Individual members of the Sp1-like/KLF family can function as activators or repressors depending on which promoter they bind and the coregulators with which they interact. A long-standing research aim has been to define the mechanisms by which Sp1-like factors and KLFs regulate gene expression and cellular function in a cell- and promoter-specific manner. Most members of this family have been identified in mammals, with at least 21 Sp1-like/KLF proteins encoded in the human genome, and members are also found in frogs, worms and flies. Sp1-like/KLF proteins have highly conserved carboxy-terminal zinc-finger domains that function in DNA binding. The amino terminus, containing the transcription activation domain, can vary significantly between family members. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
Germany | 2 | <1% |
South Africa | 2 | <1% |
United Kingdom | 2 | <1% |
Mexico | 2 | <1% |
Brazil | 1 | <1% |
Israel | 1 | <1% |
Italy | 1 | <1% |
Russia | 1 | <1% |
Other | 1 | <1% |
Unknown | 252 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 57 | 21% |
Researcher | 54 | 20% |
Student > Master | 35 | 13% |
Student > Bachelor | 27 | 10% |
Student > Doctoral Student | 14 | 5% |
Other | 47 | 17% |
Unknown | 36 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 123 | 46% |
Biochemistry, Genetics and Molecular Biology | 66 | 24% |
Medicine and Dentistry | 20 | 7% |
Neuroscience | 5 | 2% |
Immunology and Microbiology | 4 | 1% |
Other | 12 | 4% |
Unknown | 40 | 15% |