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Sp1- and Krüppel-like transcription factors

Overview of attention for article published in Genome Biology, February 2003
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3 Wikipedia pages

Citations

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813 Dimensions

Readers on

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270 Mendeley
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1 CiteULike
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Title
Sp1- and Krüppel-like transcription factors
Published in
Genome Biology, February 2003
DOI 10.1186/gb-2003-4-2-206
Pubmed ID
Authors

Joanna Kaczynski, Tiffany Cook, Raul Urrutia

Abstract

Sp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that are important components of the eukaryotic cellular transcriptional machinery. By regulating the expression of a large number of genes that have GC-rich promoters, Sp1-like/KLF transcription regulators may take part in virtually all facets of cellular function, including cell proliferation, apoptosis, differentiation, and neoplastic transformation. Individual members of the Sp1-like/KLF family can function as activators or repressors depending on which promoter they bind and the coregulators with which they interact. A long-standing research aim has been to define the mechanisms by which Sp1-like factors and KLFs regulate gene expression and cellular function in a cell- and promoter-specific manner. Most members of this family have been identified in mammals, with at least 21 Sp1-like/KLF proteins encoded in the human genome, and members are also found in frogs, worms and flies. Sp1-like/KLF proteins have highly conserved carboxy-terminal zinc-finger domains that function in DNA binding. The amino terminus, containing the transcription activation domain, can vary significantly between family members.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 270 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
Germany 2 <1%
South Africa 2 <1%
United Kingdom 2 <1%
Mexico 2 <1%
Brazil 1 <1%
Israel 1 <1%
Italy 1 <1%
Russia 1 <1%
Other 1 <1%
Unknown 252 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 57 21%
Researcher 54 20%
Student > Master 35 13%
Student > Bachelor 27 10%
Student > Doctoral Student 14 5%
Other 47 17%
Unknown 36 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 123 46%
Biochemistry, Genetics and Molecular Biology 66 24%
Medicine and Dentistry 20 7%
Neuroscience 5 2%
Immunology and Microbiology 4 1%
Other 12 4%
Unknown 40 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2022.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Genome Biology
#3,489
of 4,467 outputs
Outputs of similar age
#34,085
of 140,163 outputs
Outputs of similar age from Genome Biology
#13
of 26 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,163 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.