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Juvenile hormone regulation of Drosophila aging

Overview of attention for article published in BMC Biology, July 2013
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Title
Juvenile hormone regulation of Drosophila aging
Published in
BMC Biology, July 2013
DOI 10.1186/1741-7007-11-85
Pubmed ID
Authors

Rochele Yamamoto, Hua Bai, Adam G Dolezal, Gro Amdam, Marc Tatar

Abstract

Juvenile hormone (JH) has been demonstrated to control adult lifespan in a number of non-model insects where surgical removal of the corpora allata eliminates the hormone's source. In contrast, little is known about how juvenile hormone affects adult Drosophila melanogaster. Previous work suggests that insulin signaling may modulate Drosophila aging in part through its impact on juvenile hormone titer, but no data yet address whether reduction of juvenile hormone is sufficient to control Drosophila life span. Here we adapt a genetic approach to knock out the corpora allata in adult Drosophila melanogaster and characterize adult life history phenotypes produced by reduction of juvenile hormone. With this system we test potential explanations for how juvenile hormone modulates aging.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
Germany 1 <1%
Switzerland 1 <1%
Brazil 1 <1%
Unknown 176 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 55 30%
Researcher 34 19%
Student > Bachelor 24 13%
Student > Master 18 10%
Student > Doctoral Student 8 4%
Other 23 13%
Unknown 21 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 90 49%
Biochemistry, Genetics and Molecular Biology 42 23%
Medicine and Dentistry 5 3%
Environmental Science 4 2%
Immunology and Microbiology 4 2%
Other 12 7%
Unknown 26 14%