Title |
Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV
|
---|---|
Published in |
Retrovirology, December 2006
|
DOI | 10.1186/1742-4690-3-94 |
Pubmed ID | |
Authors |
Sarah K Wootton, Michael J Metzger, Kelly L Hudkins, Charles E Alpers, Denis York, James C DeMartini, A Dusty Miller |
Abstract |
Jaagsiekte sheep retrovirus (JSRV) causes a lethal lung cancer in sheep and goats. Expression of the JSRV envelope (Env) protein in mouse lung, by using a replication-defective adeno-associated virus type 6 (AAV6) vector, induces tumors resembling those seen in sheep. However, the mouse and sheep tumors have not been carefully compared to determine if Env expression alone in mice can account for the disease features observed in sheep, or whether additional aspects of virus replication in sheep are important, such as oncogene activation following retrovirus integration into the host cell genome. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 36 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 32% |
Student > Ph. D. Student | 9 | 24% |
Student > Master | 5 | 13% |
Student > Bachelor | 4 | 11% |
Lecturer > Senior Lecturer | 2 | 5% |
Other | 2 | 5% |
Unknown | 4 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 37% |
Veterinary Science and Veterinary Medicine | 6 | 16% |
Medicine and Dentistry | 6 | 16% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Immunology and Microbiology | 2 | 5% |
Other | 1 | 3% |
Unknown | 4 | 11% |