Title |
An M2e-based synthetic peptide vaccine for influenza A virus confers heterosubtypic protection from lethal virus challenge
|
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Published in |
Virology Journal, July 2013
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DOI | 10.1186/1743-422x-10-227 |
Pubmed ID | |
Authors |
Ji-Hong Ma, Fu-Ru Yang, Hai Yu, Yan-Jun Zhou, Guo-Xin Li, Meng Huang, Feng Wen, Guangzhi Tong |
Abstract |
Vaccination is considered as the most effective preventive method to control influenza. The hallmark of influenza virus is the remarkable variability of its major surface glycoproteins, HA and NA, which allows the virus to evade existing anti-influenza immunity in the target population. So it is necessary to develop a novel vaccine to control animal influenza virus. Also we know that the ectodomain of influenza matrix protein 2 (M2e) is highly conserved in animal influenza A viruses, so a vaccine based on the M2e could avoid several drawbacks of the traditional vaccines. In this study we designed a novel tetra-branched multiple antigenic peptide (MAP) based vaccine, which was constructed by fusing four copies of M2e to one copy of foreign T helper (Th) cell epitope, and then investigated its immune responses. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 23% |
Student > Master | 7 | 18% |
Student > Ph. D. Student | 5 | 13% |
Student > Doctoral Student | 4 | 10% |
Student > Bachelor | 4 | 10% |
Other | 3 | 8% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 30% |
Immunology and Microbiology | 10 | 25% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Chemistry | 2 | 5% |
Social Sciences | 1 | 3% |
Other | 3 | 8% |
Unknown | 10 | 25% |