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An M2e-based synthetic peptide vaccine for influenza A virus confers heterosubtypic protection from lethal virus challenge

Overview of attention for article published in Virology Journal, July 2013
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Citations

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Title
An M2e-based synthetic peptide vaccine for influenza A virus confers heterosubtypic protection from lethal virus challenge
Published in
Virology Journal, July 2013
DOI 10.1186/1743-422x-10-227
Pubmed ID
Authors

Ji-Hong Ma, Fu-Ru Yang, Hai Yu, Yan-Jun Zhou, Guo-Xin Li, Meng Huang, Feng Wen, Guangzhi Tong

Abstract

Vaccination is considered as the most effective preventive method to control influenza. The hallmark of influenza virus is the remarkable variability of its major surface glycoproteins, HA and NA, which allows the virus to evade existing anti-influenza immunity in the target population. So it is necessary to develop a novel vaccine to control animal influenza virus. Also we know that the ectodomain of influenza matrix protein 2 (M2e) is highly conserved in animal influenza A viruses, so a vaccine based on the M2e could avoid several drawbacks of the traditional vaccines. In this study we designed a novel tetra-branched multiple antigenic peptide (MAP) based vaccine, which was constructed by fusing four copies of M2e to one copy of foreign T helper (Th) cell epitope, and then investigated its immune responses.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 23%
Student > Master 7 18%
Student > Ph. D. Student 5 13%
Student > Doctoral Student 4 10%
Student > Bachelor 4 10%
Other 3 8%
Unknown 8 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 30%
Immunology and Microbiology 10 25%
Biochemistry, Genetics and Molecular Biology 2 5%
Chemistry 2 5%
Social Sciences 1 3%
Other 3 8%
Unknown 10 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2013.
All research outputs
#20,196,270
of 22,714,025 outputs
Outputs from Virology Journal
#2,868
of 3,035 outputs
Outputs of similar age
#170,414
of 194,246 outputs
Outputs of similar age from Virology Journal
#79
of 88 outputs
Altmetric has tracked 22,714,025 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,035 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,246 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.