Title |
A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
|
---|---|
Published in |
Journal of Neuroinflammation, July 2013
|
DOI | 10.1186/1742-2094-10-91 |
Pubmed ID | |
Authors |
Irene Paterniti, Daniela Impellizzeri, Rosanna Di Paola, Michele Navarra, Salvatore Cuzzocrea, Emanuela Esposito |
Abstract |
It has recently been demonstrated that palmitoylethanolamide (PEA), an endogenous lipid amide belonging to the N-acylethanolamine family, exerts neuroprotection in central nervous system (CNS) pathologies. In recent studies, we have demonstrated that treatment with PEA significantly reduced inflammatory secondary events associated with spinal cord injury (SCI). Since oxidative stress is considered to play an important role in neuroinflammatory disorders, in the present work we studied a new composite, a formulation including PEA and the antioxidant compound luteolin (Lut), subjected to an ultramicronization process, co-ultraPEALut. We investigated the effect of co-ultraPEALut (in the respective fixed doses of 10:1 in mass) in both an ex vivo organotypic spinal cord culture model and an in vivo model of SCI. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 2% |
Australia | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 56 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 20% |
Student > Bachelor | 8 | 14% |
Student > Ph. D. Student | 8 | 14% |
Student > Doctoral Student | 6 | 10% |
Student > Master | 4 | 7% |
Other | 7 | 12% |
Unknown | 14 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 20% |
Biochemistry, Genetics and Molecular Biology | 9 | 15% |
Neuroscience | 7 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Agricultural and Biological Sciences | 5 | 8% |
Other | 8 | 14% |
Unknown | 13 | 22% |