Title |
SISH/CISH or qPCR as alternative techniques to FISH for determination of HER2 amplification status on breast tumors core needle biopsies: a multicenter experience based on 840 cases
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Published in |
BMC Cancer, July 2013
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DOI | 10.1186/1471-2407-13-351 |
Pubmed ID | |
Authors |
Jocelyne Jacquemier, Frédérique Spyratos, Benjamin Esterni, Marie-Joëlle Mozziconacci, Martine Antoine, Laurent Arnould, Sarab Lizard, Philippe Bertheau, Jacqueline Lehmann-Che, Cécile Blanc Fournier, Sophie Krieger, Frédéric Bibeau, Pierre-Jean Lamy, Marie Pierre Chenard, Michèle Legrain, Jean-Marc Guinebretière, Delphine Loussouarn, Gaëtan MacGrogan, Isabelle Hostein, Marie Christine Mathieu, Ludovic Lacroix, Alexander Valent, Yves Marie Robin, Françoise Revillion, Magali Lacroix Triki, Aline Seaume, Anne Vincent Salomon, Patricia de Cremoux, Geneviève Portefaix, Luc Xerri, Sophie Vacher, Ivan Bièche, Frédérique Penault-Llorca |
Abstract |
Until now, FISH has been the gold standard technique to identify HER2 amplification status in ambiguous cases of breast cancer. Alternative techniques have been developed to increase the capacities of investigating HER2 amplification status. The aims of this multicenter study in a large series of breast cancer patients were to prospectively compare the level of performance of CISH, SISH, and qPCR alternative techniques on paraffin-embedded core biopsies with "gold standard FISH" for evaluation of HER2 amplification status. |
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Geographical breakdown
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Brazil | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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Mexico | 1 | 2% |
France | 1 | 2% |
Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 22% |
Researcher | 8 | 15% |
Student > Master | 5 | 9% |
Other | 4 | 7% |
Student > Doctoral Student | 4 | 7% |
Other | 13 | 24% |
Unknown | 9 | 16% |
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Agricultural and Biological Sciences | 12 | 22% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
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Psychology | 1 | 2% |
Other | 6 | 11% |
Unknown | 9 | 16% |