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Mendeley readers
| Title |
Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction
|
|---|---|
| Published in |
Retrovirology, July 2013
|
| DOI | 10.1186/1742-4690-10-76 |
| Pubmed ID | |
| Authors |
Dragana Slavkovic Lukic, Agnes Hotz-Wagenblatt, Janet Lei, Ann-Mareen Räthe, Michael Mühle, Joachim Denner, Carsten Münk, Martin Löchelt |
| Abstract |
APOBEC3 (A3) proteins restrict viral replication by cytidine deamination of viral DNA genomes and impairing reverse transcription and integration. To escape this restriction, lentiviruses have evolved the viral infectivity factor (Vif), which binds A3 proteins and targets them for proteolytic degradation. In contrast, foamy viruses (FVs) encode Bet proteins that allow replication in the presence of A3, apparently by A3 binding and/or sequestration, thus preventing A3 packaging into virions and subsequent restriction. Due to a long-lasting FV-host coevolution, Bet proteins mainly counteract restriction by A3s from their cognate or highly related host species. |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 32% |
| Student > Master | 6 | 19% |
| Student > Bachelor | 4 | 13% |
| Researcher | 3 | 10% |
| Other | 2 | 6% |
| Other | 3 | 10% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 39% |
| Biochemistry, Genetics and Molecular Biology | 7 | 23% |
| Immunology and Microbiology | 3 | 10% |
| Veterinary Science and Veterinary Medicine | 2 | 6% |
| Medicine and Dentistry | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 3 | 10% |