Title |
FiloDetect: automatic detection of filopodia from fluorescence microscopy images
|
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Published in |
BMC Systems Biology, July 2013
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DOI | 10.1186/1752-0509-7-66 |
Pubmed ID | |
Authors |
Sharmin Nilufar, Anne A Morrow, Jonathan M Lee, Theodore J Perkins |
Abstract |
Filopodia are small cellular projections that help cells to move through and sense their environment. Filopodia play crucial roles in processes such as development and wound-healing. Also, increases in filopodia number or size are characteristic of many invasive cancers and are correlated with increased rates of metastasis in mouse experiments. Thus, one possible route to developing anti-metastatic therapies is to target factors that influence the filopodia system. Filopodia can be detected by eye using confocal fluorescence microscopy, and they can be manually annotated in images to quantify filopodia parameters. Although this approach is accurate, it is slow, tedious and not entirely objective. Manual detection is a significant barrier to the discovery and quantification of new factors that influence the filopodia system. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 1% |
Hungary | 1 | 1% |
Italy | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 68 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 25% |
Student > Bachelor | 11 | 15% |
Researcher | 10 | 14% |
Student > Master | 7 | 10% |
Student > Doctoral Student | 6 | 8% |
Other | 13 | 18% |
Unknown | 7 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 24% |
Agricultural and Biological Sciences | 17 | 24% |
Engineering | 6 | 8% |
Neuroscience | 5 | 7% |
Medicine and Dentistry | 5 | 7% |
Other | 10 | 14% |
Unknown | 12 | 17% |