Title |
Distribution of CCR5-Delta32, CCR5 promoter 59029 A/G, CCR2-64I and SDF1-3’A genetic polymorphisms in HIV-1 infected and uninfected patients in the West Region of Cameroon
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Published in |
BMC Research Notes, July 2013
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DOI | 10.1186/1756-0500-6-288 |
Pubmed ID | |
Authors |
Céline Nguefeu Nkenfou, Linda Chapdeleine Mouafo Mekue, Christelle Tafou Nana, Jules Roger Kuiate |
Abstract |
Genetic variants of the genes encoding human immunodeficiency virus-1 (HIV-1) co-receptors and their ligands, like CC-chemokine receptor 5 delta 32 mutation (CCR5-Delta32), CCR5 promoter A/G (Adenine/Guanine), CC-chemokine receptor 2 mutation 64 isoleucine (CCR2-64I) and the stromal cell-derived factor 3'A mutation (SDF1-3'A), are involved in the susceptibility to HIV-1 infection and progression. The prevalence of these mutations varies by region. However, little is known about their distribution in the population of Dschang, located in the west region of Cameroon. The prevalence of HIV in the west region of Cameroon is lower than elsewhere in Cameroon. The objectives of this study were to determine the distribution of four AIDS Related Gene (ARG) variants in HIV-infected and non-infected population of Cameroon especially in the west region and to estimate the contribution of these variants to the susceptibility or resistance to HIV infection. We also aimed to evaluate the effectiveness of genotyping using dried blood spot (DBS) samples. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 54 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 11 | 20% |
Student > Ph. D. Student | 9 | 16% |
Student > Bachelor | 7 | 13% |
Student > Doctoral Student | 7 | 13% |
Student > Postgraduate | 5 | 9% |
Other | 9 | 16% |
Unknown | 8 | 14% |
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Medicine and Dentistry | 14 | 25% |
Agricultural and Biological Sciences | 13 | 23% |
Biochemistry, Genetics and Molecular Biology | 8 | 14% |
Nursing and Health Professions | 5 | 9% |
Social Sciences | 2 | 4% |
Other | 4 | 7% |
Unknown | 10 | 18% |