Title |
Intrinsic disorder in putative protein sequences
|
---|---|
Published in |
Proteome Science, June 2012
|
DOI | 10.1186/1477-5956-10-s1-s19 |
Pubmed ID | |
Authors |
Uros Midic, Zoran Obradovic |
Abstract |
Intrinsically disordered proteins (IDPs) and regions (IDRs) perform a variety of crucial biological functions despite lacking stable tertiary structure under physiological conditions in vitro. State-of-the-art sequence-based predictors of intrinsic disorder are achieving per-residue accuracies over 80%. In a genome-wide study of intrinsic disorder in human genome we observed a big difference in predicted disorder content between confirmed and putative human proteins. We investigated a hypothesis that this discrepancy is not correct, and that it is due to incorrectly annotated parts of the putative protein sequences that exhibit some similarities to confirmed IDRs, which lead to high predicted disorder content. |
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