Title |
Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study
|
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Published in |
BMC Medical Genomics, January 2013
|
DOI | 10.1186/1471-2350-14-20 |
Pubmed ID | |
Authors |
Tyren M Dodgen, Warren E Hochfeld, Heidi Fickl, Sahle M Asfaha, Chrisna Durandt, Paul Rheeder, Britt I Drögemöller, Galen E B Wright, Louise Warnich, Christiaan DJ Labuschagne, Antoinette van Schalkwyk, Andrea Gaedigk, Michael S Pepper |
Abstract |
Adverse drug reactions and lack of therapeutic efficacy associated with currently prescribed pharmacotherapeutics may be attributed, in part, to inter-individual variability in drug metabolism. Studies on the pharmacogenetics of Cytochrome P450 (CYP) enzymes offer insight into this variability. The objective of this study was to compare the AmpliChip CYP450 Test® (AmpliChip) to alternative genotyping platforms for phenotype prediction of CYP2C19 and CYP2D6 in a representative cohort of the South African population. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 3 | 4% |
Italy | 1 | 1% |
Thailand | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 66 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 19% |
Researcher | 13 | 18% |
Student > Ph. D. Student | 11 | 15% |
Student > Bachelor | 6 | 8% |
Other | 6 | 8% |
Other | 14 | 19% |
Unknown | 8 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 35% |
Biochemistry, Genetics and Molecular Biology | 20 | 28% |
Medicine and Dentistry | 7 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Computer Science | 1 | 1% |
Other | 4 | 6% |
Unknown | 11 | 15% |