Title |
An integrated hierarchical Bayesian approach to normalizing left-censored microRNA microarray data
|
---|---|
Published in |
BMC Genomics, July 2013
|
DOI | 10.1186/1471-2164-14-507 |
Pubmed ID | |
Authors |
Jia Kang, Ethan Yixun Xu |
Abstract |
MicroRNAs (miRNAs) are small endogenous ssRNAs that regulate target gene expression post-transcriptionally through the RNAi pathway. A critical pre-processing procedure for detecting differentially expressed miRNAs is normalization, aiming at removing the between-array systematic bias. Most normalization methods adopted for miRNA data are the same methods used to normalize mRNA data; but miRNA data are very different from mRNA data mainly because of possibly larger proportion of differentially expressed miRNA probes, and much larger percentage of left-censored miRNA probes below detection limit (DL). Taking the unique characteristics of miRNA data into account, we present a hierarchical Bayesian approach that integrates normalization, missing data imputation, and feature selection in the same model. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 12% |
United Kingdom | 1 | 6% |
Denmark | 1 | 6% |
Unknown | 13 | 76% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 41% |
Student > Ph. D. Student | 4 | 24% |
Professor | 2 | 12% |
Student > Master | 2 | 12% |
Other | 1 | 6% |
Other | 0 | 0% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 35% |
Biochemistry, Genetics and Molecular Biology | 3 | 18% |
Mathematics | 2 | 12% |
Computer Science | 2 | 12% |
Medicine and Dentistry | 2 | 12% |
Other | 1 | 6% |
Unknown | 1 | 6% |