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An integrated hierarchical Bayesian approach to normalizing left-censored microRNA microarray data

Overview of attention for article published in BMC Genomics, July 2013
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Title
An integrated hierarchical Bayesian approach to normalizing left-censored microRNA microarray data
Published in
BMC Genomics, July 2013
DOI 10.1186/1471-2164-14-507
Pubmed ID
Authors

Jia Kang, Ethan Yixun Xu

Abstract

MicroRNAs (miRNAs) are small endogenous ssRNAs that regulate target gene expression post-transcriptionally through the RNAi pathway. A critical pre-processing procedure for detecting differentially expressed miRNAs is normalization, aiming at removing the between-array systematic bias. Most normalization methods adopted for miRNA data are the same methods used to normalize mRNA data; but miRNA data are very different from mRNA data mainly because of possibly larger proportion of differentially expressed miRNA probes, and much larger percentage of left-censored miRNA probes below detection limit (DL). Taking the unique characteristics of miRNA data into account, we present a hierarchical Bayesian approach that integrates normalization, missing data imputation, and feature selection in the same model.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 12%
United Kingdom 1 6%
Denmark 1 6%
Unknown 13 76%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 41%
Student > Ph. D. Student 4 24%
Professor 2 12%
Student > Master 2 12%
Other 1 6%
Other 0 0%
Unknown 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 35%
Biochemistry, Genetics and Molecular Biology 3 18%
Mathematics 2 12%
Computer Science 2 12%
Medicine and Dentistry 2 12%
Other 1 6%
Unknown 1 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2013.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from BMC Genomics
#8,709
of 11,244 outputs
Outputs of similar age
#159,591
of 209,852 outputs
Outputs of similar age from BMC Genomics
#128
of 175 outputs
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