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Mendeley readers
| Title |
Evaluation of the impact of immediate versus WHO recommendations-guided antiretroviral therapy initiation on HIV incidence: the ANRS 12249 TasP (Treatment as Prevention) trial in Hlabisa sub-district, KwaZulu-Natal, South Africa: study protocol for a cluster randomised controlled trial
|
|---|---|
| Published in |
Trials, July 2013
|
| DOI | 10.1186/1745-6215-14-230 |
| Pubmed ID | |
| Authors |
Collins C Iwuji, Joanna Orne-Gliemann, Frank Tanser, Sylvie Boyer, Richard J Lessells, France Lert, John Imrie, Till Bärnighausen, Claire Rekacewicz, Brigitte Bazin, Marie-Louise Newell, François Dabis, ANRS 12249 TasP study group |
| Abstract |
Antiretroviral therapy (ART) suppresses HIV viral load in all body compartments and so limits the risk of HIV transmission. It has been suggested that ART not only contributes to preventing transmission at individual but potentially also at population level. This trial aims to evaluate the effect of ART initiated immediately after identification/diagnosis of HIV-infected individuals, regardless of CD4 count, on HIV incidence in the surrounding population. The primary outcome of the overall trial will be HIV incidence over two years. Secondary outcomes will include i) socio-behavioural outcomes (acceptability of repeat HIV counselling and testing, treatment acceptance and linkage to care, sexual partnerships and quality of life); ii) clinical outcomes (mortality and morbidity, retention into care, adherence to ART, virologic failure and acquired HIV drug resistance), iii) cost-effectiveness of the intervention. The first phase will specifically focus on the trial's secondary outcomes. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| South Africa | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 40% |
| Practitioners (doctors, other healthcare professionals) | 2 | 40% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 399 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | <1% |
| United Kingdom | 1 | <1% |
| Australia | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 394 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 82 | 21% |
| Researcher | 68 | 17% |
| Student > Ph. D. Student | 51 | 13% |
| Student > Bachelor | 22 | 6% |
| Student > Doctoral Student | 17 | 4% |
| Other | 69 | 17% |
| Unknown | 90 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 132 | 33% |
| Nursing and Health Professions | 42 | 11% |
| Social Sciences | 35 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
| Agricultural and Biological Sciences | 9 | 2% |
| Other | 54 | 14% |
| Unknown | 117 | 29% |