Title |
Gene expression changes with age in skin, adipose tissue, blood and brain
|
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Published in |
Genome Biology, July 2013
|
DOI | 10.1186/gb-2013-14-7-r75 |
Pubmed ID | |
Authors |
Daniel Glass, Ana Viñuela, Matthew N Davies, Adaikalavan Ramasamy, Leopold Parts, David Knowles, Andrew A Brown, Åsa K Hedman, Kerrin S Small, Alfonso Buil, Elin Grundberg, Alexandra C Nica, Paola Di Meglio, Frank O Nestle, Mina Ryten, the UK Brain Expression consortium, the MuTHER consortium, Richard Durbin, Mark I McCarthy, Panagiotis Deloukas, Emmanouil T Dermitzakis, Michael E Weale, Veronique Bataille, Tim D Spector |
Abstract |
Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines in 856 female twins in the age range of 39-85 years. Additionally, we investigated genotypic variants involved in genotype-by-age interactions to understand how the genomic regulation of gene expression alters with age. |
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Other | 2 | 5% |
Unknown | 14 | 35% |
Demographic breakdown
Type | Count | As % |
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Scientists | 10 | 25% |
Practitioners (doctors, other healthcare professionals) | 4 | 10% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Unknown | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 3 | <1% |
United Kingdom | 3 | <1% |
Spain | 2 | <1% |
Brazil | 1 | <1% |
Canada | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Switzerland | 1 | <1% |
China | 1 | <1% |
Other | 3 | <1% |
Unknown | 363 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 97 | 25% |
Researcher | 89 | 23% |
Student > Master | 40 | 10% |
Student > Bachelor | 33 | 9% |
Professor > Associate Professor | 16 | 4% |
Other | 52 | 14% |
Unknown | 58 | 15% |
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Biochemistry, Genetics and Molecular Biology | 85 | 22% |
Medicine and Dentistry | 25 | 6% |
Computer Science | 16 | 4% |
Neuroscience | 11 | 3% |
Other | 34 | 9% |
Unknown | 71 | 18% |