Title |
Myeloid derived suppressor cells – a new therapeutic target in the treatment of cancer
|
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Published in |
Journal for Immunotherapy of Cancer, July 2013
|
DOI | 10.1186/2051-1426-1-10 |
Pubmed ID | |
Authors |
Robert Wesolowski, Joseph Markowitz, William E Carson |
Abstract |
Myeloid Derived Suppressor Cells (MDSC) are a heterogeneous population of immature myeloid cells that are increased in states of cancer, inflammation and infection. In malignant states, MDSC are induced by tumor secreted growth factors. MDSC play an important part in suppression of host immune responses through several mechanisms such as production of arginase 1, release of reactive oxygen species and nitric oxide and secretion of immune-suppressive cytokines. This leads to a permissive immune environment necessary for the growth of malignant cells. MDSC may also contribute to angiogenesis and tumor invasion. This review focuses on currently available strategies to inhibit MDSC in the treatment of cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 43% |
France | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Scientists | 2 | 29% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 1% |
Netherlands | 2 | <1% |
Chile | 1 | <1% |
Germany | 1 | <1% |
Unknown | 336 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 74 | 22% |
Researcher | 70 | 20% |
Student > Master | 35 | 10% |
Student > Doctoral Student | 25 | 7% |
Student > Bachelor | 25 | 7% |
Other | 65 | 19% |
Unknown | 50 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 83 | 24% |
Medicine and Dentistry | 74 | 22% |
Immunology and Microbiology | 45 | 13% |
Biochemistry, Genetics and Molecular Biology | 38 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 15 | 4% |
Other | 32 | 9% |
Unknown | 57 | 17% |