Title |
Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes
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Published in |
BMC Neuroscience, July 2013
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DOI | 10.1186/1471-2202-14-75 |
Pubmed ID | |
Authors |
Marco Milanese, Daniela Tardito, Laura Musazzi, Giulia Treccani, Alessandra Mallei, Tiziana Bonifacino, Cecilia Gabriel, Elisabeth Mocaer, Giorgio Racagni, Maurizio Popoli, Giambattista Bonanno |
Abstract |
Growing compelling evidence from clinical and preclinical studies has demonstrated the primary role of alterations of glutamatergic transmission in cortical and limbic areas in the pathophysiology of mood disorders. Chronic antidepressants have been shown to dampen endogenous glutamate release from rat hippocampal synaptic terminals and to prevent the marked increase of glutamate overflow induced by acute behavioral stress in frontal/prefrontal cortex. Agomelatine, a new antidepressant endowed with MT1/MT2 agonist and 5-HT2C serotonergic antagonist properties, has shown efficacy at both preclinical and clinical levels. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 2% |
Unknown | 46 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 17% |
Researcher | 6 | 13% |
Student > Master | 6 | 13% |
Student > Bachelor | 4 | 9% |
Student > Postgraduate | 4 | 9% |
Other | 10 | 21% |
Unknown | 9 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 10 | 21% |
Medicine and Dentistry | 10 | 21% |
Agricultural and Biological Sciences | 10 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Other | 2 | 4% |
Unknown | 10 | 21% |