Title |
Comprehensive characterization of malignant phyllodes tumor by whole genomic and proteomic analysis: biological implications for targeted therapy opportunities
|
---|---|
Published in |
Orphanet Journal of Rare Diseases, July 2013
|
DOI | 10.1186/1750-1172-8-112 |
Pubmed ID | |
Authors |
Denis L Fontes Jardim, Anthony Conley, Vivek Subbiah |
Abstract |
Phyllodes tumors are uncommon breast tumors that account for less than 0.5% of all breast malignancies. After metastases develop, the prognosis is poor, with very few patients living more than 1 year. The biology of this unusual cancer is not understood and, consequently, no potential targets for treatments are currently available. There has been an exponential increase in the number of commercially available tumor profiling services. Herein, we report a case of metastatic malignant phyllodes tumor for which a comprehensive molecular analysis was performed by using Clinical Laboratory Improvement Amendments (CLIA)-certified labs, providing new insights into the potential opportunities for molecularly targeted therapies for this extremely rare disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 19% |
Student > Bachelor | 8 | 17% |
Student > Master | 6 | 13% |
Student > Postgraduate | 5 | 10% |
Other | 5 | 10% |
Other | 6 | 13% |
Unknown | 9 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 26 | 54% |
Agricultural and Biological Sciences | 5 | 10% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Social Sciences | 1 | 2% |
Chemistry | 1 | 2% |
Other | 0 | 0% |
Unknown | 11 | 23% |