Title |
Angiotensin II Produces Nociceptive Behavior through Spinal AT1 Receptor-Mediated p38 Mitogen-Activated Protein Kinase Activation in Mice
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Published in |
Molecular Pain, January 2013
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DOI | 10.1186/1744-8069-9-38 |
Pubmed ID | |
Authors |
Wataru Nemoto, Osamu Nakagawasai, Fukie Yaoita, Syu-Ichi Kanno, Shin Yomogida, Masaaki Ishikawa, Takeshi Tadano, Koichi Tan-No |
Abstract |
It has been demonstrated that angiotensin II (Ang II) participates in either the inhibition or the facilitation of nociceptive transmission depending on the brain area. Neuronal Ang II is locally synthesized not only in the brain, but also in the spinal cord. Though the spinal cord is an important area for the modulation of nociception, the role of spinal Ang II in nociceptive transmission remains unclear. Therefore, in order to elucidate the role of Ang II in nociceptive transmission in the spinal cord, we examined the effect of intrathecal (i.t.) administration of Ang II into mice. |
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