Title |
epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data
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Published in |
Genome Biology, February 2017
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DOI | 10.1186/s13059-017-1168-4 |
Pubmed ID | |
Authors |
Martin Vincent, Kamilla Mundbjerg, Jakob Skou Pedersen, Gangning Liang, Peter A. Jones, Torben Falck Ørntoft, Karina Dalsgaard Sørensen, Carsten Wiuf |
Abstract |
The study of epigenetic heterogeneity at the level of individual cells and in whole populations is the key to understanding cellular differentiation, organismal development, and the evolution of cancer. We develop a statistical method, epiG, to infer and differentiate between different epi-allelic haplotypes, annotated with CpG methylation status and DNA polymorphisms, from whole-genome bisulfite sequencing data, and nucleosome occupancy from NOMe-seq data. We demonstrate the capabilities of the method by inferring allele-specific methylation and nucleosome occupancy in cell lines, and colon and tumor samples, and by benchmarking the method against independent experimental data. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 40% |
Poland | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 40% |
Scientists | 2 | 40% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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New Zealand | 1 | 2% |
Spain | 1 | 2% |
United States | 1 | 2% |
Unknown | 56 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 21 | 36% |
Researcher | 12 | 20% |
Student > Master | 8 | 14% |
Student > Doctoral Student | 3 | 5% |
Student > Bachelor | 3 | 5% |
Other | 7 | 12% |
Unknown | 5 | 8% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 17 | 29% |
Agricultural and Biological Sciences | 16 | 27% |
Computer Science | 6 | 10% |
Medicine and Dentistry | 2 | 3% |
Mathematics | 2 | 3% |
Other | 10 | 17% |
Unknown | 6 | 10% |