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epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data

Overview of attention for article published in Genome Biology, February 2017
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Title
epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data
Published in
Genome Biology, February 2017
DOI 10.1186/s13059-017-1168-4
Pubmed ID
Authors

Martin Vincent, Kamilla Mundbjerg, Jakob Skou Pedersen, Gangning Liang, Peter A. Jones, Torben Falck Ørntoft, Karina Dalsgaard Sørensen, Carsten Wiuf

Abstract

The study of epigenetic heterogeneity at the level of individual cells and in whole populations is the key to understanding cellular differentiation, organismal development, and the evolution of cancer. We develop a statistical method, epiG, to infer and differentiate between different epi-allelic haplotypes, annotated with CpG methylation status and DNA polymorphisms, from whole-genome bisulfite sequencing data, and nucleosome occupancy from NOMe-seq data. We demonstrate the capabilities of the method by inferring allele-specific methylation and nucleosome occupancy in cell lines, and colon and tumor samples, and by benchmarking the method against independent experimental data.

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The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
New Zealand 1 2%
Spain 1 2%
United States 1 2%
Unknown 56 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 36%
Researcher 12 20%
Student > Master 8 14%
Student > Doctoral Student 3 5%
Student > Bachelor 3 5%
Other 7 12%
Unknown 5 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 29%
Agricultural and Biological Sciences 16 27%
Computer Science 6 10%
Medicine and Dentistry 2 3%
Mathematics 2 3%
Other 10 17%
Unknown 6 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2017.
All research outputs
#15,742,933
of 25,382,440 outputs
Outputs from Genome Biology
#3,969
of 4,468 outputs
Outputs of similar age
#182,369
of 323,958 outputs
Outputs of similar age from Genome Biology
#54
of 63 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,468 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,958 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.