Title |
Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis
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Published in |
BMC Complementary Medicine and Therapies, July 2013
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DOI | 10.1186/1472-6882-13-201 |
Pubmed ID | |
Authors |
Mariana S Camargo, Aline M Prieto, Flavia A Resende, Paula K Boldrin, Cassia RP Cardoso, Mariana F Fernández, José Manuel Molina-Molina, Nicolás Olea, Wagner Vilegas, Osmany Cuesta-Rubio, Eliana A Varanda |
Abstract |
Brown propolis is the major type of propolis found in Cuba; its principal component is nemorosone, the major constituent of Clusia rosea floral resins. Nemorosone has received increasing attention due to its strong in vitro anti-cancer action. The citotoxicity of nemorosone in several human cancer cell lines has been reported and correlated to the direct action it has on the estrogen receptor (ER). Breast cancer can be treated with agents that target estrogen-mediated signaling, such as antiestrogens. Phytoestrogen can mimic or modulate the actions of endogenous estrogens and the treatment of breast cancer with phytoestrogens may be a valid strategy, since they have shown anti-cancer activity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 16% |
Student > Ph. D. Student | 8 | 14% |
Student > Bachelor | 6 | 11% |
Researcher | 6 | 11% |
Professor | 4 | 7% |
Other | 11 | 20% |
Unknown | 12 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 10 | 18% |
Medicine and Dentistry | 7 | 13% |
Agricultural and Biological Sciences | 6 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 6 | 11% |
Unknown | 19 | 34% |