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Herbal-drug interaction induced rhabdomyolysis in a liposarcoma patient receiving trabectedin

Overview of attention for article published in BMC Complementary Medicine and Therapies, July 2013
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3 X users

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57 Mendeley
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Title
Herbal-drug interaction induced rhabdomyolysis in a liposarcoma patient receiving trabectedin
Published in
BMC Complementary Medicine and Therapies, July 2013
DOI 10.1186/1472-6882-13-199
Pubmed ID
Authors

Sabino Strippoli, Vito Lorusso, Anna Albano, Michele Guida

Abstract

Rhabdomyolysis is an uncommon side effect of trabectedin which is used for the second line therapy of metastatic sarcoma after anthracycline and ifosfamide failure. This side effect may be due to pharmacokinetic interactions caused by shared mechanisms of metabolism involving the cytochrome P450 (CYP) system in the liver. Here, for the first time in literature, we describe the unexpected onset of heavy toxicity, including rhabdomyolysis, after the fourth course of trabectedin in a patient with retroperitoneal liposarcoma who at the same time was taking an alternative herbal medicine suspected of triggering this adverse event.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 18%
Other 8 14%
Student > Master 8 14%
Researcher 7 12%
Student > Ph. D. Student 5 9%
Other 10 18%
Unknown 9 16%
Readers by discipline Count As %
Medicine and Dentistry 20 35%
Pharmacology, Toxicology and Pharmaceutical Science 8 14%
Nursing and Health Professions 5 9%
Psychology 4 7%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 3 5%
Unknown 14 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2013.
All research outputs
#14,756,074
of 22,715,151 outputs
Outputs from BMC Complementary Medicine and Therapies
#1,831
of 3,620 outputs
Outputs of similar age
#117,902
of 198,188 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#41
of 84 outputs
Altmetric has tracked 22,715,151 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,620 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,188 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.