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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hypometabolism as a therapeutic target in Alzheimer's disease
|
|---|---|
| Published in |
BMC Neuroscience, December 2008
|
| DOI | 10.1186/1471-2202-9-s2-s16 |
| Pubmed ID | |
| Authors |
Lauren C Costantini, Linda J Barr, Janet L Vogel, Samuel T Henderson |
| Abstract |
The pathology of Alzheimer's disease (AD) is characterized by cerebral atrophy in frontal, temporal, and parietal regions, with senile plaques, dystrophic neurites, and neurofibrillar tangles within defined areas of the brain. Another characteristic of AD is regional hypometabolism in the brain. This decline in cerebral glucose metabolism occurs before pathology and symptoms manifest, continues as symptoms progress, and is more severe than that of normal aging. Ketone bodies are an efficient alternative fuel for cells that are unable to metabolize glucose or are 'starved' of glucose. AC-1202 is designed to elevate serum ketone levels safely. We previously showed that treatment with AC-1202 in patients with mild-to-moderate AD improves memory and cognition. Treatment outcomes were influenced by apolipoprotein E genotype status. These data suggest that AC-1202 may be an effective treatment for cognitive dysfunction by providing an alternative substrate for use by glucose-compromised neurons. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Japan | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 217 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Italy | 1 | <1% |
| Austria | 1 | <1% |
| Canada | 1 | <1% |
| Brazil | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 209 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 37 | 17% |
| Student > Master | 32 | 15% |
| Student > Ph. D. Student | 29 | 13% |
| Student > Bachelor | 22 | 10% |
| Student > Doctoral Student | 16 | 7% |
| Other | 42 | 19% |
| Unknown | 39 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 20% |
| Medicine and Dentistry | 37 | 17% |
| Neuroscience | 28 | 13% |
| Biochemistry, Genetics and Molecular Biology | 14 | 6% |
| Psychology | 11 | 5% |
| Other | 33 | 15% |
| Unknown | 50 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 51. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2022.
All research outputs
#818,228
of 25,202,494 outputs
Outputs from BMC Neuroscience
#11
of 1,291 outputs
Outputs of similar age
#2,613
of 180,501 outputs
Outputs of similar age from BMC Neuroscience
#2
of 22 outputs
Altmetric has tracked 25,202,494 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,291 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,501 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.