Title |
Adipose tissue arachidonic acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques
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Published in |
Lipids in Health and Disease, January 2013
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DOI | 10.1186/1476-511x-12-7 |
Pubmed ID | |
Authors |
Michael S Nielsen, Marie-Louise M Grønholdt, Mogens Vyberg, Kim Overvad, Annette Andreasen, Karen-Margrete Due, Erik B Schmidt |
Abstract |
The content of arachidonic acid in adipose tissue is positively associated with the risk of myocardial infarction, whereas the content of eicosapentaenoic acid in adipose tissue has been reported to be negatively associated with the risk of myocardial infarction. Both arachidonic acid and eicosapentaenoic acid are substrates for the synthesis of pro-inflammatory leukotrienes and leukotrienes derived from eicosapentaenoic acid are generally much less potent. In this study we hypothesized that a high content of arachidonic acid in adipose tissue would reflect a high formation of arachidonic acid derived leukotrienes and a high expression of 5-lipoxygenase in atherosclerotic plaques. Likewise, we hypothesized that a high content of eicosapentaenoic acid in adipose tissue would reflect a low formation of arachidonic acid derived leukotrienes and a low expression of 5-lipoxygenase in plaques. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 21% |
Researcher | 3 | 21% |
Student > Doctoral Student | 1 | 7% |
Student > Ph. D. Student | 1 | 7% |
Professor | 1 | 7% |
Other | 2 | 14% |
Unknown | 3 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 29% |
Agricultural and Biological Sciences | 3 | 21% |
Biochemistry, Genetics and Molecular Biology | 2 | 14% |
Nursing and Health Professions | 1 | 7% |
Chemistry | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 21% |