Title |
Hereditary cancer syndromes in Latino populations: genetic characterization and surveillance guidelines
|
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Published in |
Hereditary Cancer in Clinical Practice, January 2017
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DOI | 10.1186/s13053-017-0063-z |
Pubmed ID | |
Authors |
Marcia Cruz-Correa, Julyann Pérez-Mayoral, Julie Dutil, Miguel Echenique, Rafael Mosquera, Keila Rivera-Román, Sharee Umpierre, Segundo Rodriguez-Quilichini, Maria Gonzalez-Pons, Myrta I. Olivera, Sherly Pardo, on behalf of the Puerto Rico Clinical Cancer Genetics Consortia |
Abstract |
Hereditary cancer predisposition syndromes comprise approximately 10% of diagnosed cancers; however, familial forms are believed to account for up to 30% of some cancers. In Hispanics, the most commonly diagnosed hereditary cancers include colorectal cancer syndromes such as, Lynch Syndrome, Familial Adenomatous Polyposis, and hereditary breast and ovarian cancer syndromes. Although the incidence of hereditary cancers is low, patients diagnosed with hereditary cancer syndromes are at high-risk for developing secondary cancers. Furthermore, the productivity loss that occurs after cancer diagnosis in these high-risk patients has a negative socio-economic impact. This review summarizes the genetic basis, phenotype characteristics, and the National Comprehensive Cancer Network's screening, testing, and surveillance guidelines for the leading hereditary cancer syndromes. The aim of this review is to promote a better understanding of cancer genetics and genetic testing in Hispanic patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 12% |
Student > Master | 6 | 11% |
Student > Doctoral Student | 6 | 11% |
Researcher | 5 | 9% |
Other | 5 | 9% |
Other | 12 | 21% |
Unknown | 16 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 32% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Agricultural and Biological Sciences | 5 | 9% |
Nursing and Health Professions | 2 | 4% |
Psychology | 2 | 4% |
Other | 3 | 5% |
Unknown | 21 | 37% |