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On the role of tyrosine phosphatases as negative regulators of STAT signaling in breast cancers: new findings and future perspectives

Overview of attention for article published in Breast Cancer Research, July 2013
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Title
On the role of tyrosine phosphatases as negative regulators of STAT signaling in breast cancers: new findings and future perspectives
Published in
Breast Cancer Research, July 2013
DOI 10.1186/bcr3437
Pubmed ID
Authors

Michel L Tremblay

Abstract

The increasing importance of signal transducer and activator of transcription 3 (STAT3) expression in human cancers has led several laboratories to examine in detail the expression of one of its major negative regulators in oncogenesis--the T-cell protein tyrosine phosphatase, nonreceptor type 2 (PTPN2). A recent paper by Shields and colleagues points to the associate depletion of PTPN2 in STAT3-positive breast cancers. We examine these findings and reflect on the mechanism of action of PTPN2 and the consequences of its modulation for STAT3 downstream signaling.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 11%
United Kingdom 1 6%
France 1 6%
Austria 1 6%
Unknown 13 72%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 44%
Student > Master 4 22%
Professor > Associate Professor 2 11%
Researcher 2 11%
Student > Bachelor 1 6%
Other 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 39%
Computer Science 3 17%
Biochemistry, Genetics and Molecular Biology 2 11%
Medicine and Dentistry 2 11%
Arts and Humanities 1 6%
Other 3 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2013.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from Breast Cancer Research
#1,705
of 2,052 outputs
Outputs of similar age
#159,562
of 209,801 outputs
Outputs of similar age from Breast Cancer Research
#23
of 28 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,801 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.