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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Microbiota activates IMD pathway and limits Sindbis infection in Aedes aegypti
|
|---|---|
| Published in |
Parasites & Vectors, February 2017
|
| DOI | 10.1186/s13071-017-2040-9 |
| Pubmed ID | |
| Authors |
Ana Beatriz Ferreira Barletta, Maria Clara L. Nascimento-Silva, Octávio A. C. Talyuli, José Henrique M. Oliveira, Luiza Oliveira Ramos Pereira, Pedro L. Oliveira, Marcos Henrique F. Sorgine |
| Abstract |
Aedes aegypti is the main vector of important arboviruses such as dengue, Zika and chikungunya. During infections mosquitoes can activate the immune pathways Toll, IMD and JAK/STAT to limit pathogen replication. Here, we evaluate the immune response profile of Ae. aegypti against Sindbis virus (SINV). We analyzed gene expression of components of Toll, IMD and JAK/STAT pathways and showed that a blood meal and virus infection upregulated aaREL2 in a microbiota-dependent fashion, since this induction was prevented by antibiotic. The presence of the microbiota activates IMD and impaired the replication of SINV in the midgut. Constitutive activation of the IMD pathway, by Caspar depletion, leads to a decrease in microbiota levels and an increase in SINV loads. Together, these results suggest that a blood meal is able to activate innate immune pathways, through a nutrient induced growth of microbiota, leading to upregulation of aaREL2 and IMD activation. Microbiota levels seemed to have a reciprocal interaction, where the proliferation of the microbiota activates IMD pathway that in turn controls bacterial levels, allowing SINV replication in Ae. aegypti mosquitoes. The activation of the IMD pathway seems to have an indirect effect in SINV levels that is induced by the microbiota. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 20% |
| United States | 2 | 20% |
| Spain | 1 | 10% |
| Belgium | 1 | 10% |
| Switzerland | 1 | 10% |
| Germany | 1 | 10% |
| Unknown | 2 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 70% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
| Scientists | 1 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Brazil | 1 | <1% |
| Unknown | 131 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 21% |
| Researcher | 20 | 15% |
| Student > Ph. D. Student | 17 | 13% |
| Student > Bachelor | 13 | 10% |
| Student > Doctoral Student | 12 | 9% |
| Other | 22 | 16% |
| Unknown | 22 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 25% |
| Biochemistry, Genetics and Molecular Biology | 31 | 23% |
| Immunology and Microbiology | 21 | 16% |
| Medicine and Dentistry | 5 | 4% |
| Nursing and Health Professions | 4 | 3% |
| Other | 16 | 12% |
| Unknown | 23 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2023.
All research outputs
#2,515,783
of 25,248,775 outputs
Outputs from Parasites & Vectors
#465
of 5,929 outputs
Outputs of similar age
#45,669
of 317,424 outputs
Outputs of similar age from Parasites & Vectors
#10
of 155 outputs
Altmetric has tracked 25,248,775 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,929 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,424 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 155 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.