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The impact of dysfunctional tear films and optical aberrations on chronic migraine

Overview of attention for article published in Eye and Vision, February 2017
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Title
The impact of dysfunctional tear films and optical aberrations on chronic migraine
Published in
Eye and Vision, February 2017
DOI 10.1186/s40662-017-0070-1
Pubmed ID
Authors

Rohit Shetty, Kalyani Deshpande, Chaitra Jayadev, Kareeshma Wadia, Pooja Mehta, Rushad Shroff, Harsha L. Rao

Abstract

Migraine is a multifactorial disorder with complex neuronal and vascular mechanisms that encompasses a wide clinical spectrum of symptoms, including ocular manifestations. Dry eye disease and dysfunction of ocular somatosensory pathways have been implicated in the pathogenesis. The current study investigates the association between a dysfunctional tear film and ocular aberrations with migraine. Sixty eyes of 30 patients with migraine and 60 eyes of 30 controls were studied. Dry eye evaluation included Schirmer's test, tear film break-up time, corneal esthesiometry and lipid layer analysis using Lipiview® interferometer. Wavefront aberrations were measured using Optical Path Difference before performing the dry eye evaluation. The intraocular light scatter was quantified using the objective scatter index (OSI) of the optical quality analysis system. Measured parameters were compared between the migraine and the control group using independent sample t-test. Statistical analysis was performed using commercial software. A p value of ≤ 0.05 was considered statistically significant. There were 19 females and 11 males in each group. Statistically significant difference was found between the two groups with respect to total aberrations (p = 0.049), higher order aberrations (p = 0.009), coma (p = 0.03), spherical aberrations (p = 0.018), Lipiview interferometric coloric units (p < 0.001) and OSI (p < 0.001). Trefoil (p = 0.26) and TBUT (p = 0.398) were not significantly different between both groups. Ocular aberrations are higher in patients with migraine as compared with controls. Tear film abnormalities add to the aberrations in otherwise asymptomatic patients and may also be associated with migraineous attacks. Treating the ocular surface to obtain a healthy tear film might introduce a potential modifiable factor in the prevention of migraneous attacks.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Other 6 26%
Student > Postgraduate 3 13%
Student > Bachelor 2 9%
Student > Master 2 9%
Student > Ph. D. Student 1 4%
Other 2 9%
Unknown 7 30%
Readers by discipline Count As %
Medicine and Dentistry 8 35%
Neuroscience 2 9%
Biochemistry, Genetics and Molecular Biology 1 4%
Nursing and Health Professions 1 4%
Unknown 11 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2017.
All research outputs
#14,334,914
of 22,955,959 outputs
Outputs from Eye and Vision
#64
of 239 outputs
Outputs of similar age
#176,295
of 310,771 outputs
Outputs of similar age from Eye and Vision
#4
of 9 outputs
Altmetric has tracked 22,955,959 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 239 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,771 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.