Title |
The degree of microbiome complexity influences the epithelial response to infection
|
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Published in |
BMC Genomics, August 2009
|
DOI | 10.1186/1471-2164-10-380 |
Pubmed ID | |
Authors |
Jeffrey J Mans, Kate von Lackum, Cassandra Dorsey, Shaun Willis, Shannon M Wallet, Henry V Baker, Richard J Lamont, Martin Handfield |
Abstract |
The human microflora is known to be extremely complex, yet most pathogenesis research is conducted in mono-species models of infection. Consequently, it remains unclear whether the level of complexity of a host's indigenous flora can affect the virulence potential of pathogenic species. Furthermore, it remains unclear whether the colonization by commensal species affects a host cell's response to pathogenic species beyond the direct physical saturation of surface receptors, the sequestration of nutrients, the modulation of the physico-chemical environment in the oral cavity, or the production of bacteriocins. Using oral epithelial cells as a model, we hypothesized that the virulence of pathogenic species may vary depending on the complexity of the flora that interacts with host cells. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
France | 1 | 1% |
Canada | 1 | 1% |
Australia | 1 | 1% |
Unknown | 79 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 25 | 30% |
Student > Ph. D. Student | 16 | 19% |
Professor > Associate Professor | 9 | 11% |
Professor | 7 | 8% |
Other | 5 | 6% |
Other | 16 | 19% |
Unknown | 6 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 35 | 42% |
Medicine and Dentistry | 19 | 23% |
Biochemistry, Genetics and Molecular Biology | 10 | 12% |
Unspecified | 2 | 2% |
Immunology and Microbiology | 2 | 2% |
Other | 6 | 7% |
Unknown | 10 | 12% |