Title |
Ursodeoxycholic acid counteracts celecoxib in reduction of duodenal polyps in patients with familial adenomatous polyposis: a multicentre, randomized controlled trial
|
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Published in |
Orphanet Journal of Rare Diseases, August 2013
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DOI | 10.1186/1750-1172-8-118 |
Pubmed ID | |
Authors |
Bjorn WH van Heumen, Hennie MJ Roelofs, M Elisa Vink-Börger, Evelien Dekker, Elisabeth MH Mathus-Vliegen, Jan Dees, Jan J Koornstra, Alexandra MJ Langers, Iris D Nagtegaal, Ellen Kampman, Wilbert HM Peters, Fokko M Nagengast, |
Abstract |
Due to prophylactic colectomy, mortality in patients with familial adenomatous polyposis (FAP) has changed, with duodenal cancer currently being the main cause of death. Although celecoxib reduces duodenal polyp density in patients with FAP, its long-term use may increase the risk of cardiovascular events and alternatives need to be explored. Preclinical studies suggest that the combination of celecoxib with ursodeoxycholic acid (UDCA) is a potentially effective strategy. We performed a randomized, double-blind, placebo-controlled trial to investigate the effect of celecoxib and UDCA co-treatment on duodenal adenomatosis in patients with FAP. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 60 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 17% |
Other | 8 | 13% |
Student > Master | 6 | 10% |
Researcher | 6 | 10% |
Student > Ph. D. Student | 6 | 10% |
Other | 12 | 20% |
Unknown | 12 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 52% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Nursing and Health Professions | 3 | 5% |
Agricultural and Biological Sciences | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 5 | 8% |
Unknown | 13 | 22% |