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Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants

Overview of attention for article published in Retrovirology, January 2013
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Title
Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants
Published in
Retrovirology, January 2013
DOI 10.1186/1742-4690-10-3
Pubmed ID
Authors

Genevieve G Fouda, Tatenda Mahlokozera, Jesus F Salazar-Gonzalez, Maria G Salazar, Gerald Learn, Surender B Kumar, S Moses Dennison, Elizabeth Russell, Katherine Rizzolo, Frederick Jaeger, Fangping Cai, Nathan A Vandergrift, Feng Gao, Beatrice Hahn, George M Shaw, Christina Ochsenbauer, Ronald Swanstrom, Steve Meshnick, Victor Mwapasa, Linda Kalilani, Susan Fiscus, David Montefiori, Barton Haynes, Jesse Kwiek, S Munir Alam, Sallie R Permar

Abstract

Breastfeeding is a leading cause of infant HIV-1 infection in the developing world, yet only a minority of infants exposed to HIV-1 via breastfeeding become infected. As a genetic bottleneck severely restricts the number of postnatally-transmitted variants, genetic or phenotypic properties of the virus Envelope (Env) could be important for the establishment of infant infection. We examined the efficiency of virologic functions required for initiation of infection in the gastrointestinal tract and the neutralization sensitivity of HIV-1 Env variants isolated from milk of three postnatally-transmitting mothers (n = 13 viruses), five clinically-matched nontransmitting mothers (n = 16 viruses), and seven postnatally-infected infants (n = 7 postnatally-transmitted/founder (T/F) viruses).

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
South Africa 1 1%
Unknown 72 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 23%
Student > Ph. D. Student 10 13%
Student > Bachelor 7 9%
Student > Master 7 9%
Other 5 7%
Other 13 17%
Unknown 16 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 21%
Medicine and Dentistry 14 19%
Nursing and Health Professions 8 11%
Immunology and Microbiology 5 7%
Biochemistry, Genetics and Molecular Biology 4 5%
Other 10 13%
Unknown 18 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2013.
All research outputs
#18,342,133
of 22,715,151 outputs
Outputs from Retrovirology
#955
of 1,104 outputs
Outputs of similar age
#219,402
of 282,417 outputs
Outputs of similar age from Retrovirology
#15
of 18 outputs
Altmetric has tracked 22,715,151 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,104 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,417 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.