Title |
Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS
|
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Published in |
Nutrition & Metabolism, November 2011
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DOI | 10.1186/1743-7075-8-84 |
Pubmed ID | |
Authors |
Silvia Savastano, Rossella Valentino, Carolina Di Somma, Francesco Orio, Claudia Pivonello, Federica Passaretti, Valentina Brancato, Pietro Formisano, Annamaria Colao, Francesco Beguinot, Giovanni Tarantino |
Abstract |
Polycystic ovary syndrome (PCOS) is frequently associated with hypovitaminosis D. Vitamin D is endowed with pleiotropic effects, including insulin resistance (IR) and apoptotic pathway. Disruption of the complex mechanism that regulated ovarian apoptosis has been reported in PCOS. Phosphoprotein enriched in diabetes gene product (PED/PEA-15), an anti-apoptotic protein involved in type 2 diabetes mellitus (T2DM), is overexpressed in PCOS women, independently of obesity. Leptin-to-adiponectin ratio (L/A) is a biomarker of IR and low-grade inflammation in PCOS. The aim of the study was to investigate the levels of 25-hydroxy vitamin D (25(OH)D), and L/A, in association with PED/PEA-15 protein abundance, in both lean and overweight/obese (o/o) women with PCOS. |
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