Title |
NMDA receptor subunits have different roles in NMDA-induced neurotoxicity in the retina
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Published in |
Molecular Brain, July 2013
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DOI | 10.1186/1756-6606-6-34 |
Pubmed ID | |
Authors |
Ning Bai, Tomomi Aida, Michiko Yanagisawa, Sayaka Katou, Kenji Sakimura, Masayoshi Mishina, Kohichi Tanaka |
Abstract |
Loss of retinal ganglion cells (RGCs) is a hallmark of various retinal diseases including glaucoma, retinal ischemia, and diabetic retinopathy. N-methyl-D-aspartate (NMDA)-type glutamate receptor (NMDAR)-mediated excitotoxicity is thought to be an important contributor to RGC death in these diseases. Native NMDARs are heterotetramers that consist of GluN1 and GluN2 subunits, and GluN2 subunits (GluN2A-D) are major determinants of the pharmacological and biophysical properties of NMDARs. All NMDAR subunits are expressed in RGCs in the retina. However, the relative contribution of the different GluN2 subunits to RGC death by excitotoxicity remains unclear. |
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